Paper 7

Clinical results of FRD in cervix special staining in the examination of 1652 cases of cervical lesions

Tao Gan,  Guonv Ke, Xiaoxia Wu, Mingchen Li, Yuanjia Yang

(Department of obstetrics and gynecology, Junan Hospital of Shunde, Foshan)

Abstract:  Objective  To investigate the clinical significance of cervix special staining FRD to detect abnormal cervical lesions (CINII+). Methods  Routine pelvic examination was performed on 1652 patient from the outpatient, and then FRD cervical special staining was used for further examination. The cervical exfoliated cells were collected and fixed onto glasses using thin liquid layer technology. The patients, whose FRD cervical special staining was positive or liquid based cytology was greater than ASC-US, were further examined by colposcopy. The clinical diagnose was according to the lesion changes under colposcopy and the biopsy of acetic acid white staining. Results  Comparing to biopsy, the coincidence rates of FRD in detection of CINI, CINII, CINIII, infiltrating carcinoma were 66.7%, 75%, 80%, and 100%, respectively.  According to histopathologic characteristics of CINII , the sensitivity of FRD was 79.2%, specificity was 72.7%, and  accuracy was 80.4%. Conclusion  The FRD staining was accurate, simple to operate, comprehensive to diagnosis, visual to read results in cervical lesion examination, which could be used for effectively screening of cervix in suspicious patients and improve the accuracy of clinical diagnose.

Key words: Special cervix staining FRD, cervical lesion, liquid based cytology

Published in The Practical Journal of Cancer,2015(30)