Paper 5

Application value of folate receptor mediated FRD in diagnosis of cervical intraepithelial neoplasia and cancer

ZHANG Chao-hong, XUE Xiao-ling, DANG Rong-fang, HUANG Wei, ZHU Yan, LIU Xia-xing

(Department of Gynecology, Baoji Maternal and Child Health Hospital of Shaaxi Province, Baoji, Shaanxi, China 721000)

Abstract: Objective  To exp1ore the applcation value of folate receptor mediated FRD in the diagnosis of cervical intraepithelial neoplasia and cancer. Method 2013 March to 2013 September, 2528 outpatients and hospitalized patients with gynecological diseases from gynecological clinic were enrolled in this investigation. FRD staining was performed immediately after pelvic examination, cervical cell sampling and colposcopy partly performed comparative analysis of three kinds of results by histopathologic diagnosis standard. Results  89 cases of positive staining were found and the positive rate was 3.52%. In terms of CINⅠ, CINⅡ, CINⅢ and cancer, the concordance rate of FRD staining with tissue pathological diagnosis was 66.7% (2/3), 80.0% (4/5),50.0% (1/2) and 83.3% (5/6) respectively. Given that CINⅠand CINⅡ+ was abnormal cervical lesion, the sensitivity and specificity of FRD staining was 76.9% and 71.3%. Positive prediction rate was 28.6% and negative prediction rate was 95.4%. Conclusion  FRD staining is a rapid, simple, accurate diagnosis method, has important clinical significance of cervical precancerous lesions, cervical cancer early detection.

Key words: FRD; Cervical lesion; Folic acid; folic acid receptor; Screening; Diagnosis

Published in Chinese Journal of Laboratory Diagnosis, 2014, (8)