Folate Receptor References

Scientific papers related to folate receptor

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

Published: 15 August 2017


The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes…

Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies

Oncotarget, 2018, Vol. 9, (No. 4), pp: 4485-4495
Published: December 15, 2017


A number of folate receptor (FR) targeted small molecular drugs and monoclonal antibodies have been introduced into clinical trials to treat FR positive cancers. Because the therapeutic efficacy of these drugs depends prominently on the level of FR-α expression on the cancer cells,….

Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk human papillomavirus persistence: a nested case control study

Flatley et ai. BMC Cancer 2014, 14:803


Background: Persistent infection with one or more high-risk human papillomavirus [HR-HPV] types increases the risk of intraepithelial neoplasia and cervical cancer. A nested case-control study was conducted to investigate the importance of cervical cell folate concentration and tumour….

Targeting folate receptor alpha for cancer treatment

Oncotarget. 2016 Aug 9; 7(32): 52553–52574.
Published online 2016 May 27. doi: 10.18632/oncotarget.9651


Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen Folate Receptor alpha (FRα)…

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

Journal of Experimental & Clinical Cancer Research volume 38, Article number: 125 (2019)
Published: 12 March 2019


Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases and as targets for treatment of cancer and inflammation….

Targeting the folate receptor for the treatment of ovarian cancer

Vol 4, No 1 (February 2015)


While conventional therapies have improved the outcome for patients with ovarian cancer, the disease still accounts for the most gynecological cancer-related deaths. The development of new treatment options is needed and efforts have focused on targeted therapies which aim to improve patient outcome by increasing anti-tumor activity while minimizing toxicity. The frequent overexpression of folate receptor α (FRα)…

Advances in targeting the folate receptor in the treatment/imaging of cancers

Chemical Science
Issue 4, 2018


The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression on a large number of tumours. Consequently, the FR has been exploited by many diagnostic and therapeutic tools to allow targeted delivery to, and imaging of, cancer cells…

Expression of Folate Receptor Type α in Relation to Cell Type, Malignancy, and Differentiation in Ovary, Uterus, and Cervix

AACR Publications
Published September 1999


The folate receptor (FR) type α is known to be frequently overexpressed in ovarian cancer and is the target for a number of novel experimental cancer therapies. The relative levels of FR expression among specific cell types and its relationship…

Folate Receptor Alpha as a Therapeutic Target for Ovarian Cancer

Published: Friday, April 19, 2019


With the introduction of agents such as bevacizumab and PARP inhibitors, the treatment spectrum for ovarian cancer has evolved from a broad utilization of cytotoxic agents into more tailored approaches.1Additional molecular targets are being investigated in an effort to improve the clinical outcomes of recurrent ovarian cancer….
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