Clinical Studies

Application of folate receptor-mediated cervical epithelial tissue specific staining in screening cervical cancer

Clinical Studies

ZHANG Chunhua, WU Ling, YANG hui, et al. Deparment of Gynecology, Huaian Maternity and Child Health Care Hospital, Huaian, 223002, CHINA

Abstract Objective To investigate the application value of folate receptor-mediated cervical epithelial tissue specific staining ( FRD) in screening cervical cancer.
Methods The screening for cervical cancer was carried out in 800 women using two methods of FRD and human papilloma virus testing for cervical cancer (HPVE6/E7), of whom the patients with FRD or HPV E6/E7 positive received cervical biopsy via colposcopy. Taking pathological results as the golden standard. The diagnostic efficiency of FRD and HPV E6/E7 techniques was compared.

Results The cervical biopsy was performed in 180 cases and pathological coincidence rates for N/A and CIN2: were 69. 81 % and 89.90% using FRD, which were higher than 41.51% and 67. 57% using 1-IPV E6/E7 (P<0.05). For screening cervical lesions of CIN2 or higher, the sensitivity of FRD was similar to that of HPV E6/E7 (88.76% vs.83.15% (p<0.05), but specificity of FRD was higher than that of HPV E6/E7 (57.14% vs 38.46%) (P<0.05).

Conclusion Compared to HPV E6/E7 method, FRD technique has the advantages of higher specificity, quicker diagnosis, less cost, and more suitable for screening the cervical lesions of CIN2 or higher.

Key words Folate receptor-mediated, cervical epithelial tissue specific staining; human papilloma virus testing; Cervical cancer

Published in Jiangsu Med J, April 2017, Vol 43, No. 8

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