Clinical Studies

A special epithelial staining agent: Folate Receptor-mediated Detection (FRD™) effectively and conveniently screens patients with cervical cancer

Clinical Studies

Meng-han Lu, Ling-yun Hu, Xin-xin Du, Min Yang, Wei-yi Zhang, Ke Huang, Li-an Li, Ya-li Li, Shu-fang Jiang*

(The Department of Gynecology & Obstetrics, The Chinese People’s Liberation Army General Hospital, Beijing, 100853, China)

Abstract: High-quality screening with cytology has markedly reduced mortality from cervical cancer. However, it needs experienced pathologists to review and make final decisions. We have developed folic acid receptor-mediated diagnosis (FRD) kits to screen patients with cervical cancer. We conduct present study aim to assess clinical significances of FRD in screening cervical cancer. A total of 169 patients were enrolled at Chinese People’s liberation Army (PLA) general hospital. We compared diagnostic significances of FRD with thinprep cytology test (TCT). Meanwhile, colposcopy was also performed to confirm any lesion suspicious for cervical cancer. The sensitivity and specificity of FRD were 71.93% and 66.07% in diagnosis cervical cancer. The positive predictive values (PPV) was 51.90%. The negative predictive values (NPV) was 82.22%. Youden index was 0.38. Moreover, sensitivity and specificity of TCT were 73.68% and 61.61%. PPV, NPV and Youden index for TCT were 49.41%, 82.14% and 0.35. Overall, FRD have high values of sensitivity, specificity and Youden index. However, this difference failed to statistical significance. FRD have comparable diagnostic significance with TCT, but more conveniently. Therefore, FRD might serve as one effective method to screen cervical cancer. Especially for those patients lived in remote regions of China, where cytology was unavailable.

Keywords: Cervical lesion; Folic acid Receptor-mediated Diagnosis; Folate receptor.

Accepted by <International Journal of Clinical and Experimental Medicine>

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